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Medical & Health » Diseases » G00-G99. Diseases of the nervous system » G10-G13. Systemic atrophies primarily affecting the central nervous system » G10. Huntington's disease

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    What is Huntington Disease?

    By: user18789, 2007/04/07 09:36

    Huntington disease (HD) is a neurodegenerative disorder caused by an expansion of the polyglutamine tract in the N-terminal huntingtin (Htt). Htt is a substrate of caspases and calpains, the proteases involved in initiation and execution of neuronal apoptosis. Caspase- and calpain-mediated cleavage of mutant Htt results in the production of toxic Nterminal Htt fragments. Recent studies suggest that Htt cleavage may be a crucial step in the pathogenesis of HD and may be a potential molecular target for HD therapy.

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